Figure 1 | International Journal of Obesity

Figure 1

From: Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery

Figure 1

Altered circulating microRNAs and targeted signaling pathways. (a) The Roux-en-Y gastric bypass (RYGB) surgery altered the expression of 14 circulating microRNAs with 3 upregulated (yellow) and 11 downregulated (blue) in the RYGB-operated animals (n=4) compared with sham controls (n=4). P-values are derived from two-tailed t-test. (b) The heat map with two-way clustering shows clear grouping of RYGB and SHAM animals based on 14 significantly altered microRNAs. (c) The predicted pathways that these microRNAs can target are ranked according to the number of potentially involved microRNAs. P-values represent a statistical overrepresentation or underrepresentation of the genes in the predicted microRNA target list relative to the reference pathway gene list.

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