Figure 5 | International Journal of Obesity

Figure 5

From: Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans

Figure 5

Effects of PGD2 on macrophage polarisation capacity. (a) Expression of polarisation markers in macrophages, treated with HQL-79 or vehicle during differentiation, in response to treatment with lipopolysaccharide (LPS) or interleukin-4 (IL4) for 24 h. (b) Cytokine production expressed as absolute cytokine levels (left panels) and induction from baseline (right panels). N=4 separate BMDM cultures derived from 12-week-old C57Bl/6 male mice. (c) Correlations of H-PGDS expression in macrophages isolated from subcutaneous WAT (scWAT) with peripheral insulin sensitivity in humans. (d) Correlations of GLUT4 expression in adipocytes from scWAT with peripheral insulin sensitivity in humans. (e) Correlation of H-PGDS expression in macrophages from scWAT with GLUT4 expression in adipocytes from scWAT in humans. N=17 subjects. Rd=rate of glucose disposal. *P<0.05.

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