Figure 1
Body weight and food intake of wild-type mice treated with C12TPP. (a) Body weight change in mice maintained on a chow diet acclimated at 21 or 30 °C and treated with vehicle (control) or C12TPP (treated). The C12TPP dose was 50 μmol per (day•kg body weight) for 7 days. The values are the means±s.e.m. of five to six mice in each group. Student t-test for unpaired data with unequal variance was used for comparison. *Significant differences between the control and C12TPP-treated groups; #significant difference between 21 and 30 °C. Time course of body weight (b), body fat mass (c), body lean mass (d), water (e) and food intake (f) of mice on a HFD before C12TPP treatment and during 16 days of C12TPP treatment. The period of treatment is indicated by arrows. The values are the means±s.e.m. (n=8 in each group). The statistical analysis of effects was conducted with a repeated measures 2-way analysis of variance (ANOVA): in b, c and f (time: P<0.001; treatment: P<0.001; interaction P<0.001); in d (time: P<0.01; treatment: P<0.001; interaction P<0.05). Asterisks in graphs indicate significant differences between the control and C12TPP-treated groups.
