Table 1 Baseline characteristics of randomized trial participants

From: Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial

Characteristic

Liraglutide 3.0 mg (N=180)

Placebo (N=179)

Sex—N (%)

 Female

51 (28.3)

50 (27.9)

 Male

129 (71.7)

129 (72.1)

Age—years

48.6±9.9

48.4±9.5

Racea—N (%)

 White

130 (72.2)

135 (75.4)

 Black or African American

33 (18.3)

36 (20.1)

 Asian

13 (7.2)

3 (1.7)

 Native Hawaiian or other Pacific Islander

1 (0.6)

2 (1.1)

 Other

3 (1.7)

3 (1.7)

Hispanic/Latino ethnicity—N (%)

19 (10.6)

24 (13.4)

OSA severity category—N (%)

 Moderate (AHI 15–29.9 events/h)

60 (33.3)

58 (32.4)

Females/Males—%

45.0/55.0

44.8/55.2

 Severe (AHI⩾30 events/h)

120 (66.7)

121 (67.6)

Females/Males—%

20.0/80.0

19.8/80.2

AHIb—events/h

49.0±27.5

49.3±27.5

Waist circumference—cm

122.3±14.5

122.7±14.9

Neck circumference—cm

44.5±4.5

44.2±4.6

Pulse—beats/min

73.6±9.1

71.5±9.9

Body-mass indexc

38.9±6.4

39.4±7.4

Body-mass index categories—N (%)

 27–29.9, overweight

0

1 (0.6)

 30–34.9, obese class I

58 (32.2)

51 (28.5)

 35–39.9, obese class II

59 (32.8)

62 (34.6)

 ⩾40, obese class III

63 (35.0)

65 (36.3)

Cholesterol—mg/dl

 Total

190.4±20.2

191.5±18.6

 LDL

111.6±28.9

111.4±26.8

 HDL

45.7±22.8

44.5±28.6

 VLDL

28.0±53.3

28.8±64.7

Triglycerides—mg/dl

140.3±55.9

144.7±83.5

Urinary albumin:creatinine ratio (mg/g)

3.4±286.5

3.7±293.2

Prediabetes—N (%)d

115 (63.9)

112 (62.6)

Dyslipidemia—N (%)e

65 (36.1)

55 (30.7)

Hypertension—N (%)e

75 (41.7)

77 (43.0)

Depression or mood disorders—N (%)

29 (16.1)

30 (16.8)

  1. Abbreviations: AHI, apnea-hypopnea index; CV, coefficient of variation; HDL, high-density lipoprotein; LDL, low-density lipoprotein; OSA, obstructive sleep apnea; VLDL, very-low-density lipoprotein. Values are means±s.d., unless otherwise noted. For lipids and cardiovascular biomarkers, values are geometric means±CV. To convert values for cholesterol to mmol/L, multiply by 0.0259.
  2. aRace was self-reported based on categories defined by the Sponsor.
  3. bDefinitions of apnea and hypopnea from the 2007 American Academy of Sleep Medicine Manual for the Scoring of Sleep and Associated Events were used.29
  4. cThe body-mass index is the weight in kilograms divided by the square of the height in meters.
  5. dPrediabetes was defined based on the HbA1c and FPG criteria of the ADA 2010 definition.33
  6. eDyslipidemia and hypertension at baseline were identified by a MedDRA preferred term search.
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