Figure 5
From: Loss of anti-contractile effect of perivascular adipose tissue in offspring of obese rats
NO synthase inhibition increases contractions in 24-week-old offspring of HFD dams. NOS inhibition with 100 μM l-NMMA increased contractions to U46619 in PVAT-denuded vessels from 24-week-old offspring of control (a) and HFD (b) dams but was more pronounced in the latter. It also led to an increase in contractions in PVAT-intact mesenteric arteries isolated from 24-week-old offspring of control (c) and HFD (d) dams, which abolished the anti-contractile effect of PVAT. Data are expressed as mean±s.e.m., n=8, *P<0.05, ****P<0.0001, two-way analysis of variance.
