Table 4 Taq1A and having a binge eating disorder or a BMI >40 kg m−2

From: A meta-analysis of the relationship between brain dopamine receptors and obesity: a matter of changes in behavior rather than food addiction?

 

Sample

Age

N

BMI

A1/A1

BMI

A1/A2

BMI

A2/A2

%

A1/A1

%

A1/A2

%

A2/A2

Comings et al.6

Tourette/ADHD

clinic

Being treated for addiction

Hospital controls

Obese >100 lb overweight

NA

387

487

 

NA

 

Percentage A1 with increasing BMI:

<25, 54.8%

30, 57.4%

35, 69.8%

40, 58.3%

>40, 87.5%

P<0.006

 

Southon et al.38

Nauruan men

Leaner BMI 36.1

Heavier BMI 52.8

Nauruan women

Leaner BMI 34.8

Heavier BMI 55.1

41.9 Years

42.8 Years

40.2 Years

40.2 Years

70 in total

 

NA

NA

 

27%

40%

16%

13%

47%

30%

NS

42%

50%

NS

27%

30%

42%

38%

Nisoli et al.32

Control BMI 23.7

Obese BMI 42.7

31.2 Years

46.9 Years

54

71

23.6

42.1

NS

23.8

43.1

1.9%

8.4%

24.4%

26.8%

NS

73.7%

64.8%

Davis et al.39

Control BMI 22.4

Obese controls BMI 39.1

Binge eating disorder BMI 34.7

33.5 Years

36.3 Years

34.8 Years

59

51

56

 

NA

 

1.7%

5.9%

3.6%

32.2%

43.1%

30.4%

NS

66.1%

51.0%

66.0%

Davis et al.70

Obese BMI =39.2

Binge eating disorder BMI-36.6

37 Years

34.7 Years

70

66

 

NA

 

7.6%

3.1%

43.9%

29.2%

P<0.001

48.5%

67.7%

Winkler et al.46

Extremely obese

BMI 41.7

46.1 Years

135

40.2

42.6

NS

41.5

1.4%

31.8%

66.6%

Ariza et al.45

Control BMI 22.1

Obese BMI 38.8

29.7 Years

31.8 Years

42

42

 

NA

 

2.4%

4.8%

26.2%

14.3%

NS

71.4%

81.0%

Carpenter et al.47

Extremely obese

BMI 43

53 Years

80

46.4

P<0.04

40.7

2.5%

43.8%

53.7%

  1. Abbreviations: ADHD, attention deficit hyperactivity disorder; BMI, body mass index (in kg m−2); NA, not available; NS, non-significant.
  2. As several studies reported average BMI just under 40 kg m−2, these were included as they were not likely to differ significantly from those 40 kg m−2.