Figure 2 | International Journal of Obesity

Figure 2

From: Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations

Figure 2

Overview of the changes observed in the metabolic profile of obese children with and without IR. Inflammation and CCM, together with the activity/contribution of the gut microbiota, were found to be altered in obesity-associated hyperinsulinemia. Metabolites that showed significant differences (P< 0.05) between IR and no-IR obese children are depicted in square box. Arrow up: increase; arrow down: decrease relative to control when the whole cohort is investigated. Male (♂) and female (♀) symbols indicate the metabolites that differ significantly between groups, when boys and girls are considered separately. FAO, fatty acid oxidation; LysoPL, Lysophospholipids.

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