Figure 3
From: Neuromodulation of orexin neurons reduces diet-induced adiposity
Pharmacosynthetic activation of orexin neurons increases SPA and energy expenditure (EE) in the hours following treatment (male, Cre::hM3Dq, N=6). (a) Schematic of treatment and recording periods. Metabolic and behavioral data collected in the home-cage (Sable Promethium; Reno, NV) following CNO (5 mg/kg; black bars) or vehicle (saline; white bars). SPA, TotalEE, ActiveEE, RestEE, and body weight are reported for (b) 24 h post-injection and divided into (c) LightsON-A (post-injection; 6hr), (d) LightsOFF (12 h), and (e) LightsON-B. *P<0.05, **P<0.01, ***P<0.001.
