Figure 5
From: Neuromodulation of orexin neurons reduces diet-induced adiposity
Repeated, daily (10 d) pharmacosynthetic activation of orexin neurons protects against weight gain in adult mice on high fat diet (N=14). Metabolic and behavioral data collected from adult (4.5 M) male Cre::hM3Dq mice. (a) Weight gain and (b) adiposity (Fat Mass grams/Lean Mass grams; EchoMRI; Plano, TX) before (d0; Chow+Veh; HFD-/CNO-; white circle or bar) and after 10 d HFD+CNO (5 mg/kg; black boxes and bars) or HFD+vehicle (veh; saline; grey triangle) treatment. Mean SPA (c), EE (d), food intake (e), and water intake (f) during 10 d of the Chow+Veh baseline period and the 10 d periods of HFD with and without CNO*P<0.05, **P<0.01, ***P<0.001.
