Figure 2 | International Journal of Obesity

Figure 2

From: Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach

Figure 2

Locus zoom plots for genome-wide significant IR loci that were replicated in individual genotyping of the first cohort. Locus zoom plots are shown for regions with top SNPs within the genes ECE on chromosome 1 (a), IL1RA on chromosome 2 (b), GNPDA1 on chromosome 5 (c), and PYGB on chromosome 20 (d). Top candidate IR genes are shown on the top of the panel with the most significant SNP indicated within the plot. Closely linked genetic map with the chromosomal physical map are shown on the x axis. The unbroken blue line indicates the recombination rate within the region (right y axis). Each filled circle represents the log10 P-value (left y axis), with the top SNPs in red, and other SNPs in the vicinity are coloured based on their degree of correlation (r2) with the top SNP.

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