Table 1 Cohorts of obese adolescents with (IR+) and without (IR−) IR

From: Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach

 

Cohort 1

Cohort 2

Whole tested population

 

IR+

IR−

IR+

IR−

IR+

IR−

Gender, n

      

 Males

48

50

39

38

87

88

 Females

50

50

40

40

90

90

Age (years)

13.8 (13.3–14.3)

12.6 (12.0–13.1)

13.9 (13.3–14.5)

13.8 (13.2–14.4)

13.8 (13.5–14.2)

13.1 (12.7–13.5)

BMI-SDS (kg m−2)

3.03 (2.93–3.14)

2.85 (2.76–2.94)

2.88 (2.77–2.98)

2.82 (2.72–2.92)

2.96 (2.89–3.04)

2.84 (2.77–2.90)

HbA1c (%)

5.20 (5.15–5.26)

5.19 (5.13–5.24)

5.15 (5.10–5.21)

5.13 (5.08–5.19)

5.18 (5.14–5.22)

5.16 (5.12–5.2)

HOMA-IR

4.62 (4.22–5.02)

1.85 (1.70–1.99)

4.57 (4.08–5.06

1.81 (1.63–1.98)

4.60 (4.29–4.91)

1.83 (1.72–1.94)

WBISI

2.23 (2.11–2.36)

5.58 (5.08–6.08)

2.28 (2.15–2.42)

5.93 (5.35–6.51)

2.26 (2.16–2.35)

5.73 (5.36–6.11)

Systolic blood pressure (mm Hg)

128.8 (126.2–131.3)

123.5 (121.0–126.1)

126.5 (123.8–129.2)

124.6 (122.2–127.1)

127.7 (125.9–129.6)

124.0 (122.2–125.8)

Diastolic blood pressure (mm Hg)

68.8 (66.6–71.0)

64.8 (63.0–66.5)

65.7 (63.7–67.7)

64.5 (62.8–66.3)

67.4 (65.9–68.9)

64.7 (63.4–65.9)

Total cholesterol (mmol L−1)

4.11 (3.98–4.25)

4.24 (4.09–4.40)

4.26 (4.06–4.46)

3.99 (3.83–4.15)

4.18 (4.06–4.30)

4.13 (4.02–4.24)

LDL (mmol L−1)

2.49 (2.37–2.60)

2.57 (2.44–2.71)

2.62 (2.45–2.80)

2.38 (2.24–2.52)

2.55 (2.45–2.65)

2.49 (2.39–2.59)

HDL (mmol L−1)

1.11 (1.06–1.16)

1.20 (1.15–1.26)

1.10 (1.04–1.15)

1.17 (1.11–1.22)

1.11 (1.07–1.14)

1.19 (1.15–1.23)

Triglycerides (mmol L−1)

1.39 (1.26–1.53)

1.07 (0.97–1.18)

1.31 (1.18–1.44)

1.04 (0.94–1.14)

1.36 (1.26–1.45)

1.06 (0.99–1.13)

  1. Abbreviations: BMI-SDS, standardized body mass index; CI, confidence interval; HbA1c, glycated haemoglobin; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment—insulin resistance; LDL, low-density lipoprotein; WBISI, whole-body insulin sensitivity index. Values are represented as mean (95% CI), except for gender where it is presented as number.
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