Table 2B Top five candidate SNPs from GWAS-pool analysis on individual samples that composed the pools

From: Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach

Sample

rs212540

rs3218888

rs252111

rs9261108

rs2258617

1. IR+

0.358

0.147

0.922

0.913

0.477

2. IR+

0.352

0.138

0.895

0.874

0.462

3. IR+

0.355

0.160

0.944

0.909

0.493

Average IR+ pool

0.355

0.148

0.920

0.899

0.477

S.e.m.

0.003

0.011

0.025

0.021

0.015

4. IR−

0.476

0.084

0.828

0.964

0.570

5. IR−

0.451

0.085

0.774

0.949

0.541

6. IR−

0.457

0.065

0.865

0.980

0.545

Average IR− pool

0.462

0.078

0.823

0.964

0.552

S.e.m.

0.013

0.011

0.046

0.016

0.016

Mean IR+ and IR−

0.408

0.113

0.871

0.931

0.515

S.e.m.

0.059

0.040

0.063

0.040

0.043

  1. Abbreviations: GWAS, genome-wide association study; IR, insulin resistance; SNP, single-nucleotide polymorphism. In Table 2B, we show frequencies of the B allele in each pool-array experiment with averages and s.e. separately for the pools IR+, IR− and combined IR+ and IR− together. Our frequency data are essentially similar to global mean allele frequency (MAF) and EUR 1K MAF, and the variability between the pools is very low.
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