Table 3 Statistical analysis for each SNP after HRM and TaqMan genotyping of individual DNAs from the first cohort of IR+ and IR− groups

From: Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach

First cohort

rs2258617 (PYGB)

rs212540 (ECE1)

rs3218888 (IL1R2)

rs252111 (GNPDA1)

 

C→T

A→G

C→T

C→T

 

Recessive

Dominant

Additive

Recessive

Dominant

Additive

Recessive

Dominant

Additive

Recessive

Dominant

Additive

OR

2.412

1.495

 

2.135

1.317

 

0.4797

NA

 

NA

0.4484

 

95% CI

1.174–4.836

0.7978–2.729

 

1.177–3.832

0.6379–2.622

 

0.2437–0.9366

NA

 

NA

0.2351–0.844

 

P-value

0.0168

0.217

0.0235

0.0164

0.4745

0.0391

0.0397

>0.9999

0.0638

0.1227

0.0169

0.0062

q-Value

0.0907

0.4367

0.1081

0.0907

0.5877

0.1278

0.1278

0.9199

0.1712

0.2822

0.0907

0.0907

1−b (a=0.05)

0.67

0.24

0.99

0.67

0.11

0.99

0.53

1

0.99

1

0.67

0.99

  1. Abbreviations: CI, confidence interval; HRM, high-resolution melting; NA, not applicable; OR, odds ratio; SNP, single-nucleotide polymorphism. Results of testing the dominant, additive and recessive models of inheritance are shown with P values, ORs and 95% CIs. A two-stage Benjamini, Krieger and Yekutieli false discovery rate (FDR) procedure for FDR was used and P-values<0.0239 were considered as significant »discoveries« and are indicated in bold text style..
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