Table 4 Statistical analysis for rs2258617 after TaqMan assay performed on original and independent cohorts and merged data from both cohorts

From: Identification of novel alleles associated with insulin resistance in childhood obesity using pooled-DNA genome-wide association study approach

 

First cohort

Second cohort

Merged cohorts

 

IR+

IR−

IR+

IR−

IR+

IR−

Gender

      

 Males

48

50

39

38

87

88

 Females

50

50

40

40

90

90

Age (years)

13.8±2.6

12.6±2.9

13.9±2.6

13.8±2.9

13.9±2.6

13.1±2.9

BMI-SDS (kg m−2)

3.0±0.5

2.8±0.5

2.9±0.5

2.8±0.4

3.0±0.5

2.8±0.4

rs2258617 (PYGB)

C→T

Recessive

Dominant

Additive

Recessive

Dominant

Additive

Recessive

Dominant

Additive

OR

2.412

1.495

 

2.33

1.137

 

2.374

0.8281

 

95% CI

1.174–4.836

0.7978–2.729

 

1.054–4.923

0.5463–2.414

 

1.397–3.97

0.5185–1.313

 

P-value

0.0168

0.217

0.0235

0.0389

0.8492

0.2456

0.001

0.4725

0.0133

q-Value

0.0907

0.4367

0.1081

0.1278

0.9199

0.4652

0.0322

0.5877

0.0907

  1. Abbreviations: BMI-SDS, standardized body mass index; CI, confidence interval; OR, odds ratio. Results of testing the dominant, additive and recessive models of inheritance are shown with P-values, ORs and 95% CIs. A two-stage Benjamini, Krieger and Yekutieli false discovery rate (FDR) procedure for FDR was used and P-values<0.0239 were considered as significant »discoveries« and are indicated in bold text style.
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