Table 1 Twenty genes enriched in gWAT of WRG mice compared to WG

From: Global transcriptome analysis identifies weight regain-induced activation of adaptive immune responses in white adipose tissue of mice

Gene symbol

Gene name

Log2 FC WC vs Weight gain

Function

Module

Irgm2

Immunity-related GTPase family M protein 2

2.22

Autophage

8 pink

Nkg7

Natural killer cell group 7 sequence

2.14

Unknown function

8 pink

Slamf6

SLAM family member 6

2.09

NK cell receptor

3 turquoise

Ikzf3

Zinc finger protein Aiolos

2.05

B-cell differentiation

8 pink

Cd3g

T-cell surface glycoprotein CD3 gamma

2.02

T-cell receptor

8 pink

Cd22

B-cell receptor CD22

1.92

B-cell receptor

3 turquoise

Ccl5

C-C motif chemokine 5

1.89

Chemokine

8 pink

Aif1

Allograft inflammatory factor 1

1.79

Phagocytosis

8 pink

Gbp2

Interferon-induced guanylate-binding protein 2

1.62

Antiviral activity

8 pink

Cd83

CD83 antigen

1.51

Costimulator

3 turquoise

Rasgrp1

RAS guanyl-releasing protein 1

1.26

T/B-cell development,

8 pink

Ly86

Lymphocyte antigen 86

1.21

Innate immune response

3 turquoise

C1qc

Complement C1q subcomponent subunit C

1.19

Innate immune response

3 turquoise

C1qb

Complement C1q subcomponent subunit B

1.17

Innate immune response

3 turquoise

H2-DMb1

Class II histocompatibility antigen, M beta 1 chain

0.88

MHC class II

5 yellow

Ptpn18

Tyrosine-protein phosphatase non-receotir type 18

0.79

Protein phosphatase

4 magenta

H2-Aa

H-2 class II histocompatibility antigen, A-K alpha chain

0.71

MHC class II

8 pink

Cd74

H-2 class II histocompatibility antigen, gamma chain

0.65

Costimulator

8 pink

Ccdc57

Coled-coil domain -containing protein 57

−0.17

Unknown function

2 red

Agt

Angiotensinogen

−2.31

Angiotensin maturation

3 turquoise

  1. Abbreviations: gWAT, gonadal white adipose tissue; WRG, weight regain.
  2. Candidates that were enriched to adipose tissue (tissue expression information was derived from ‘GeneAnalytics’ in GeneCards) were collected from module pink associated subnetworks. Bold: FDR<0.05.
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