Table 2 Top 10 upregulated and downregulated genes in the heavy (as compared with lean co-twins) in the 26 BMI-discordant monozygotic twin pairs

From: Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity

Gene symbol

Gene name

Function a

Log-fold change b

Fold change c

Adjusted P-valued

Top 10 upregulated genes in the heavy co-twins

 

Fold-up

 

 EGFL6

EGF-like-domain, multiple 6

Cell cycle progression and angiogenesis

3.15

8.90

0.00040

 UCHL1

Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Cell proliferation and apoptosis

1.76

3.39

0.0015

 SPP1

Secreted phosphoprotein 1

Cell proliferation and apoptosis

1.60

3.03

0.045

 LINC00968

Long intergenic non-protein coding RNA 968

Unknown

1.58

2.98

0.0038

 PHLDA2

Pleckstrin homoogy-like domain, family A, member 2

Regulation of glycogen metabolic process, regulation of cell migration, apoptotic process

1.53

2.88

0.00050

 CHI3L1

Chitinase 3-like 1 (cartilage glycoprotein-39)

Apoptotic process, carbohydrate metabolic process

1.28

2.43

0.025

 CCL18

Chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

Immune response, inflammatory response

1.18

2.27

0.0099

 TNMD

Tenomodulin

Endothelial cell orphogenesis, negative regulation of angiogenesis, negative regulation of endothelial cell proliferation

1.15

2.22

0.00090

 TUBB2B

Tubulin, beta 2B class IIb

Cellular protein metabolic process

1.12

2.18

0.0013

 IFI30

Interferon, gamma-inducible protein 30

Cytokine-mediated signalling pathway, immune system process

1.10

2.14

0.035

Top 10 downregulated genes in the heavy co-twins

 

Fold-down

 

 SLC272

Solute carrier family 27 (fatty acid transporter), member 2

Lipid metabolic process; fatty acid metabolic process; fatty acid transport; long-chain and very long-chain fatty acid metabolic process

−2.44

0.18

0.0016

 COL6A6

Collagen, type VI, alpha 6

Cell adhesion; collagen catabolic process

−2.29

0.20

0.00040

 C12orf39

Chromosome 12 open reading frame 39

Long-chain fatty acid import, negative regulation of appetite

−2.07

0.24

0.00040

 CA3

Carbonic anhydrase III, muscle specific

Apoptosis, cell growth, response to oxidative stress

−2.05

0.24

0.00040

 AZGP1

Alpha-2-glycoprotein 1, zinc-binding

Antigen processing and presentation, cell adhesion, immune response, negative regulation of cell proliferation

−1.47

0.36

0.0010

 AGPAT9

1-acylglycerol-3-phosphate O-acyltransferase 9

Lipid metabolic process

−1.44

0.37

0.0026

 TTC36

Tetratricopeptide repeat domain 36

Unknown

−1.41

0.38

0.0035

 CISH

Cytokine inducible SH2-containing protein

Cytokine-mediated signalling pathway, intracellular signal transduction

−1.33

0.40

0.0026

 NAALAD2

N-acetylated alpha-linked acidic dipeptidase 2

Metabolic process, proteolysis

−1.20

0.44

<0.0001

 FHOD3

Formin homology 2 domain containing 3

Protein binding

−1.16

0.45

0.0020

  1. aProvided by IPA.
  2. bA positive value shows gene upregulation in the heavier co-twin, whereas a negative log-fold change indicates gene downregulation in the heavier co-twin.
  3. cA fold change >1 means a fold change upwards and a fold change <1 means a fold change downwards.
  4. dFDR (Benjamini and Hochberg’s method). Values sorted by log-fold change.
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