Table 1 Clinical characteristics of reported cases of the clear-cell variant of central calcifying epithelial odontogenic tumor
From: Clear-cell variant of calcifying epithelial odontogenic tumor (Pindborg tumor) in the mandible
Case | Reference | Sex (Age/year) | Maximum dimension/cm | Location | Clinical presentation | Radiographic finding | Treatment/follow-up | Summary of HC/IHC/EM studies for origins of clear cells |
|---|---|---|---|---|---|---|---|---|
1 | 3 | Male (50) | 1.2 | Posterior mandible | Tender mass | Unilocular mixed radiolucency & radiopacity | Enucleation, free of disease 3 years | Not reported |
2 | 4 | Female (68) | 3.0 | Posterior mandible, left | Swelling | Unilocular mixed radiolucency & radiopacity | Curettage, recurrence at 4 months | EM: Swollen& empty→tumor cell degeneration |
3 | 5 | Female (37) | 0.5 | Anterior mandible | None | Unilocular mixed radiolucency & radiopacity | Enucleation, free of disease 13 months | HC: PAS (−) |
4 | 6 | Male (65) | Not reported | Posterior mandible, right | Swelling, paresthesia | Unilocular mixed radiolucency & radiopacity | Excision, free of disease 22 months | Not reported |
5 | 7 | Female (36) | 10 | Anterior & posterior mandible (bilateral) | Loose teeth, swelling | Multilocular mixed radiolucency & radiopacity | Enucleation, free of disease 2 years | Not reported |
6 | 8 | Male (36) | 2.5 | Anterior & premolar mandible (right) | Swelling | Unilocular radiolucency | Partial resection, free of disease 2 years | HC: PAS (+)EM: glycogen granules |
7 | 9 | Female (44) | Not reported | Anterior & posterior maxilla | Swelling | Unilocular radiolucency | Partial maxillectomy, follow-up: not reported | IHC: CK (−)EM: Birbeck's granules (+), S100 (+)→ Langerhans cell |
8 | 10 | Male (38) | 2.5 | Anterior mandible | Swelling | Unilocular mixed radiolucency & radiopacity | Resection, free of disease 2 years | EM: tonofilament remnant, desmosomesHC: PAS (+, initial; -, later stage) →tumor cell degeneration |
9 | 11 | Male (58) | 2.0 | Posterior maxilla | Loose teeth | Unilocular radiolucency | Enucleation, free of disease 10 years | EM→Langerhans cell |
10 | 12 | Female (59) | 3.8 | Posterior mandible, right | Swelling | Unilocular mixed radiolucency & radiopacity | Resection, free of disease 3 years | HC: PAS (minimal focal +); mucicarmine (−) |
11 | 13 | Female (14) | Not reported | Posterior maxilla, right | Swelling | Unilocular radiolucency; Radiopacity (at recurrence) | Partial resection, recurrence at 13 years | IHC: CK 8, 13, 19, filaggrin, anti-ameloblastoma (+)→odontogenic epithelial origin HC: PAS (+)EM: glycogen granules |
12 | 14 | Male/(27) | 1.0 | Posterior and premolar mandible | Swelling | Unilocular radiolucency | Excision, free of disease 1 year | IHC: CK (+); S-100, actin (−)HC: PAS, mucicarmine (−) |
13 | 15 | Female (44) | Not reported | Mandibular angle, right | Swelling | Multililocular mixed radiolucency & radiopacity | Enucleation, free of disease 1 year | HC: PAS (+)→glycogen granules |
14 | 16 | Male (18) | 3.5 | Anterior maxilla, right, extension to maxillary sinus | Swelling | Unilocular mixed radiolucency & radiopacity | Excision, follow-up: not reported | Not reported |
15 | Present case | Female (59) | 3.0 | Retromolar and mandibular ramus, left | Swelling | Unilocular radiolucency | Excision, free of disease 2 years | IHC: CK (+); S-100, actin (−)HC: PAS (+); mucicarmine (−) |
