Figure 2
From: KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells
KDM6B activates genes regulating odontogenic differentiation. (a) Knockdown of KDM6B by shRNA suppresses KDM6B expression in MSC differentiation. MSC/Scrsh, MSCs expressing scramble shRNA; MSC/KDM6Bsh3, MSCs expressing KDM6B shRNA. (b) Knockdown of KDM6B inhibited BMP2 expression in MSCs as determined by real-time RT-PCR. (c) Knockdown of KDM6B inhibited BMP4 expression in MSCs. (d) Knockdown of KDM6B inhibited DLX2 expression in MSCs. BMP, bone morphogenic protein; MSC, mesenchymal stem cell; RT-PCR, reverse transcription-polymerase chain reaction.
