Figure 1
From: Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw
Bacterial diversity in the tissues of Control, BP and BRONJ cohorts. (a) Band intensity profiles of DGGE gels. Marker I and II: DGGE reference markers corresponding to 16S rRNA gene fragments of the given bacterial species [Marker I: 1. F. nucleatum subsp. vincenti (ATCC 49256); 2. F. nucleatum subsp. nucleatum (ATCC 25586); 3. S. sanguinis (ATCC 10556); 4. S. oralis (ATCC 35037); 5. S. salivarus (ATCC 7073); 6. S. mutans (UA 159); 7. L. paracasei (ATCC 25598); 8. A. odontolyticus (ATCC 17929); 9. A naeslundii (ATCC 12104). Marker II: 1. F. nucleatum subsp. vincenti (ATCC 49256); 2. F. nucleatum subsp. nucleatum (ATCC 25586); 3. B. forsythus (ATCC 43037); 4. S. sanguinis (ATCC 10556); 5. S. oralis (ATCC 35037); 6. V. parvula (ATCC 17745); 7. P. intermedia (ATCC 25611); 8. A. actinomycemcomitans (ATCC 43717); 9. P. gingivalis (ATCC 33277); 10. A. odontolyticus (ATCC 17929); 11. A. naeslundii (ATCC 12104)]. (b) Cluster analysis by Dice coefficient of the bacterial fingerprints. BP, bisphosphonate; BRONJ, bisphosphonate-related osteonecrosis of the jaw; DGGE, denaturing gradient gel electrophoresis.
