Table 1 microRNAs in bone remodeling

From: The role of microRNAs in bone remodeling

Targets	miRNAs	Sample resources	References
Osteogenesis inhibited
Runx2	miR-34c
	miR-133a
	miR-135a
	miR-137
	miR-205	MC3T3-E1	[33]
	miR-217
	miR-338
	miR-23a	MC3T3-E1	[33,34]
	miR-30c	MC3T3-E1, hADSCs	[33,35,36]
	miR-204/211	MC3T3-E1, C3H10T1/2, ST2, hMSCs	[33,37,38,70]
	miR-103a	hFOB 1.19, C57BL/6J mice	[45]
Cbfβ	miR-125b	BMSCs, C3H10T1/2, ST2	[39,40,41,42]
JMJD3	miR-146a	hMSCs	[32]
Smad1	miR-30	MC3T3-E1, BMSCs	[35]
SATB2	miR-23a∼27a∼24-2	MC3T3-E1	[50]
	miR-31	hMSCs	[55]
	miR-34b/c	Mouse osteoblasts, C2C12, miR-34a/b/c^−/− mice	[52,53]
Notch1/2, JAG1	miR-34a/c	hMSCs, miR-34c Tg mice	[53,219]
Osx	miR-31	hMSCs	[62]
	miR-93	MC3T3-E1	[63]
	miR-143	MC3T3-E1	[64,66]
	miR-145	MC3T3-E1, C2C12	[65,66]
	miR-637	hMSCs	[67]
	miR-214	hMSCs	[68]
Smad1	miR-26a/b	hADSCs, USSCs	[75]
Smad5	miR-135b	hMSCs, C2C12, hUSSCs	[76,77,78]
BMPR2	miR-100	hADSCs	[80]
BMP2	miR-17-5p	hADSCs	[79]
	miR-106a
	miR-140-5p	hMSCs	[81]
TCF3	miR-17	hPDLSCs, NOD/SCID mice	[87]
CDC25A	miR-141-3p	hMSCs, ST2	[91]
ATF4	miR-214	MC3T3-E1, human osteoporotic bone specimens	[101]
COL1A1, Col5A3	miR-29a/b	Rat osteoblasts, MC3T3-E1	[140,141]
SOCS1	miR-155	MC3T3-E1	[210,211]
Fas	miR-23a	MC3T3-E1	[214]
FAK	miR-138	hMSCs, MC3T3-E1	[113]
Fgfr2	miR-233	MC3T3-E1, C3H10T1/2, ST2	[115]
	miR-338	BMSCs, OVX mice	[116]
Cx43	miR-206	C2C12, Cx43^−/− mice	[119]
Dlx5 SVCT2	miR-141/200a	MC3T3-E1 BMSCs	[120] [121]
Dlx5/Msx2	miR-124a/181a	iPS cells, hMSCs, BMSCs, MC3T3-E1, C2C12	[122,123]
IGF2	miR-30e	BMSCs, SMCs, ApoE^−/− mice	[230]
Osteogenesis promoted
Tob2	miR-322	BMSCs, MC3T3-E1, C2C12	[69]
Smurf1	miR-15	hMSCs	[159]
PPARγ	miR-20a/b	hMSCs	[133,134]
	miR-548d-5p	hMSCs	[132]
Bambi, Crim1	miR-20b	hMSCs	[133]
DDK1	miR-335-5p	C3H10T-1/2	[139]
	miR-29a/c	hFOB1.19, MC3T3-E1	[19,141]
Kremen2, SFRP2	miR-29a/c	hFOB1.19, MC3T3-E1	[19,141]
DDK2, SFRP2, SOST	miR-218	hADSCs, MC3T3-E1, BMSCs	[137,138]
Hoxa2	miR-3960	Mouse osteoblasts	[151]
Axin2	miR-let-7	hMSCs	[142]
HMGA2		hADSCs	[231]
APC	miR-27	hFOB1.19	[144]
SFRP1			[143]
HDAC1	miR-449a	Human iPS cells	[148]
HDAC4	miR-29b	MC3T3-E1, USSCs	[141,149]
HDAC5	miR-2861	Mouse osteoblasts, ST2, OVX mice	[150,151]
HDAC6	miR-22	hADSCs	[153]
HDAC9	miR-188	BMSCs, 188-Tg mice	[154]
TFG-βi/Alk5	miR-181a	MC3T3-E1, C2C12	[156]
Acvr1b	miR-210	ST2, NRG cells	[157]
Smad2/3	miR-146a	Fetal femur-derived cells	[158]
COUP-TFII	miR-194	BMSCs	[161]
	miR-302a	MC3T3, C2C12
HB-EGF	miR-96	BMSCs, MC3T3-E1,OVX mice	[163]
	miR-1192	C2C12/Runx2^Dox cells	[164]
Spry1	miR-21	hMSCs, OVX mice	[213]
SOX2		SS-AF-hMSCs	[232]
SPARC	miR-29a	ABSa15	[88]
STAT1	miR-194	BMSCs	[233]
Hoxa8	miR-196a	hADSCs	[234]
CHIP/STUB1	miR-764-5p	MC3T3-E1, mouse osteoblasts	[235]
Osteoclastogenesis inhibited
RANK	miR-503	PBMCs	[174]
TRAF6	miR-125a	PBMCs	[175]
NFATc1	miR-124	BMMs	[176]
FasL	miR-21	BMMs, osteoclast precursors, CAG-Z-miR-21-EGFP transgenic mice	[183]
CTGF	miR-26a	Murine osteoclasts	[186]
NFI-A	miR-233	RA/OA patients	[168]
SOCS1, MITF	miR-155	FNb^−/−/IFNAR1^−/− mice, RAW264.7	[211]
Tgif2	miR-34a	Tie2-cre mice, 34a-KO/Het mice, OVX mice,34a-Tg mice	[220]
DC-STAMP	miR-7b	RAW264.7	[236]
Osteoclastogenesis promoted
PIAS3	miR-9718	RAW 264.7	[172]
RhoA	miR-31	BMMs	[177]
PDCD4	miR-21	BMMs, c-Fos^−/− mice	[181]
MAFB	miR-148a	PBMCs	[184]
Pten	miR-214	BMMs, RAW 264.7, OC-214Tg mice	[200]

hMSC, human mesenchymal stem cell; BMSC, bone marrow stem cell; ADSC, adipose-derived stem cell; PDLSC, periodontal ligament stem cell; USSC, cord blood stem cell; MC3T3-E1, mouse osteoblastic cell line; C2C12, mouse premyogenic cell line; ST2, mouse bone marrow stromal cell line; SMC, aortic smooth muscle cell; hFOB1.19, human osteoblastic cell line; PBMC, peripheral blood mononuclear cell; BMM, bone marrow macrophage; RAW264.7, Murine macrophage cell line; OVX mice, ovariectomized mice; PDCD4, programmed cell death 4; MAFB, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B.

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Table 1 microRNAs in bone remodeling

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