Figure 1 | International Journal of Oral Science

Figure 1

From: Expression of p53, p21 CIP1/WAF1 and eIF4E in the adjacent tissues of oral squamous cell carcinoma: establishing the molecular boundary and a cancer progression model

Figure 1

Sub-mucosal invasion and p53, p21 CIP1/WAF and eIF4E expression in the tumour and adjacent tissues. (a) Biopsies of primary lesions and the adjacent tissues from patients were taken and divided into the following groups: T, centre of the tumour; P1, 0–0.5 cm to the tumour boundary; P2, 0.5–1 cm to the tumour boundary; P3, 1–1.5 cm to the tumour boundary; P4, 1.5–2 cm to the tumour boundary; N, normal mucosa. Then, the samples processed for immunoreactivity to p53, p21 CIP1/WAF and eIF4E. H&E staining is presented at ×100 magnification, whereas all other panels of immunohistochemical staining are presented at ×400 magnification. (b) Overall and tumour-free survival rates for the patients based on the immunohistochemical staining of eIF4E in the P4 (1.5–2 cm to the tumour boundary) regions. H&E, haematoxylin and eosin.

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