Table 3 Immunohistochemical gradient of P53 and P21 CIP1/WAF1 in OSCC, para-tumor tissue and normal mucosa

From: Expression of p53, p21 CIP1/WAF1 and eIF4E in the adjacent tissues of oral squamous cell carcinoma: establishing the molecular boundary and a cancer progression model

  

Gradation of staining

  

Groups

Number

-

+

++

+++

Positive

Positive rate/%

P53

       

 T

50

16

5

16

13

34

68 a

 P1

50

20

10

12

8

30

60 a

 P2

50

27

12

7

4

23

46 a

 P3

50

41

5

4

0

9

18 a

 P4

50

50

0

0

0

0

0 a

 N

20

20

0

0

0

0

0 a

P21 CIP1/WAF1

       

 T

50

32

13

5

0

18

36 b

 P1

50

30

15

5

0

20

40 b

 P2

50

26

17

7

0

24

48 b

 P3

50

17

15

18

0

33

66 b

 P4

50

2

16

30

2

48

96 b

 N

20

0

8

10

2

20

100 b

eIF4E

       

 T

50

0

0

29

21

50

100 c

 P1

50

14

5

18

13

36

72 c

 P2

50

26

8

12

4

24

48 c

 P3

50

31

11

8

0

19

38 c

 P4

50

35

12

3

0

15

30 c

 N

20

20

0

0

0

0

0 c

  1. OSCC, oral squamous cell carcinoma. T, centre of the tumor; P1, 0–0.5 cm to tumor boundary; P2, 0.5–1 cm to tumor boundary; P3, 1–1.5 cm to tumor boundary; P4, 1.5–2 cm to tumor boundary; N, normal mucosa.
  2. aSignificant differences of p53 expression were observed between T, P1, P2 and P3, P4 groups (P<0.05). No statistical difference of p53 expression was found between T and P1, P2 groups (P>0.05) and between P4 and N groups (P>0.05).
  3. bNo significant differences between T, P1 and P2 groups (P>0.05), or between P4 and N groups (P>0.05); statistical differences between P2 and P3 groups (P<0.001), and between P3 and P4 groups (P<0.001).
  4. cSignificant differences of eIF4E expression were observed between T, P1, P2, P3, P4 and N groups (P<0.005).
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