Figure 6 | International Journal of Oral Science

Figure 6

From: Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth

Figure 6

Immunohistochemistry analyses of ENAM, AMBL and MMP20 in the mandibular first molars from 1-day-old (P1) mice. (a) In the normal (control) mice, ENAM protein was highly concentrated in the region of the ameloblast cytoplasm, close to the basal lamina zone. (b) The anti-ENAM signal was remarkably weaker and more diffused in the Fam20A-deficient ameloblasts than in the normal cells. (c, d) The AMBL signal was stronger in the Fam20A-null ameloblasts than in the normal mice. (e, f) The immunoreactivity for MMP20 was weaker in the ameloblasts of cKO mice than in the normal mice. Arrows indicate ameloblasts. Scale bars=100 μm in all the images. cKO, conditional knock out; Ctrl, control.

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