Table 1 List of transcriptional regulators with predicted altered activity in response to S. mitis lysate.
Upstream regulator | Molecule type | Predicted activation state | Activation z-score |
|---|---|---|---|
Heat shock factor protein 1 | Transcription regulator | Activated | 3 098 |
Paired box protein Pax-7 | Transcription regulator | Activated | 3 030 |
Hairy/enhancer-of-split related with YRPW motif protein 1 | Transcription regulator | Activated | 2 586 |
Myocyte-specific enhancer factor 2C | Transcription regulator | Activated | 2 578 |
Heart- and neural crest derivatives-expressed protein 1 | Transcription regulator | Activated | 2 449 |
CCAAT/enhancer-binding protein alpha | Transcription regulator | Activated | 2 430 |
Estrogen receptor beta | Ligand-dependent nuclear receptor | Activated | 2 392 |
Aryl hydrocarbon receptor | Ligand-dependent nuclear receptor | Activated | 2 368 |
Transcription factor Sp3 | Transcription regulator | Activated | 2 360 |
Transcription factor Dp-1 | Transcription regulator | Activated | 2 330 |
X-box-binding protein 1 | Transcription regulator | Activated | 2 253 |
CCAAT/enhancer-binding protein beta | Transcription regulator | Activated | 2 224 |
Krueppel-like factor 1 | Transcription regulator | Activated | 2 213 |
Early growth response protein 1 | Transcription regulator | Activated | 2 197 |
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | Transcription regulator | Activated | 2 173 |
Methyl-CpG-binding domain protein 2 | Transcription regulator | Activated | 2 128 |
Sterol regulatory element-binding protein 1 | Transcription regulator | Activated | 2 095 |
Histone acetyltransferase KAT5 | Transcription regulator | Activated | 2 025 |
WW domain-containing transcription regulator protein 1 | Transcription regulator | Activated | 2 000 |
Cyclic AMP-responsive element-binding protein 3-like protein 4 | Transcription regulator | Activated | 2 000 |
Hepatic leukemia factor | Transcription regulator | Inhibited | −2 000 |
Transcriptional repressor protein YY1 | Transcription regulator | Inhibited | −2 021 |
COP9 signalosome complex subunit 5 | Transcription regulator | Inhibited | −2 155 |
Transcription regulator protein BACH1 | Transcription regulator | Inhibited | −2 172 |
Nuclear factor 1 C-type | Transcription regulator | Inhibited | −2 236 |
Death domain-associated protein 6 | Transcription regulator | Inhibited | −2 392 |
Kelch-like ECH-associated protein 1 | Transcription regulator | Inhibited | −2 408 |
Nuclear receptor ROR-alpha | Ligand-dependent nuclear receptor | Inhibited | −2 579 |
Proto-oncogene c-Rel | Transcription regulator | Inhibited | −2 868 |
