Figure 3
From: Doxycycline induces bone repair and changes in Wnt signalling
Representative HE staining (× 400) photomicrographs of alveolar tissue on the 7th and 14th days after tooth extractions. For both protocols, there was a significant increase in the number of osteoblasts (black arrows) after DOX treatment compared with that in the CTL. (a, b) vs CTL (7th and 14th days), P<0.000 1 and P=0.000 9, respectively; (c, d) vs CTL (7th and 14th days), P<0.000 1 and P<0.000 1, respectively; (e, f) vs CTL (7th day) and vs DOX25 (7th day), P<0.001 7 and P<0.002 3, respectively; (g, h) vs CTL (7th day) and vs DOX25 (7th day), P<0.001 9 and P<0.002 0, respectively (Two-way ANOVA and Tukey test for multiple comparisons). HE, hematoxylin-eosin; CTL, control; DOX10, doxycycline 10 mg·kg−1; DOX25, doxycycline 25 mg·kg−1.
