Figure 4
From: Doxycycline induces bone repair and changes in Wnt signalling
Representative HE staining photomicrographs (× 400) of alveolar tissue on the 7th and 14th days after tooth extraction. For both protocols, there was a significant decrease in the number of osteoclasts (black arrows) after DOX treatment, as compared with that in the CTL. (a) vs CTL (7th day), P=0.006 0; (b, c) vs CTL (7th and 14th days), P<0.000 3 and P<0.021 4, respectively; (d, e) vs CTL (7th and 14th days), P<0.000 4 and P<0.024 9, respectively; (f, g) vs CTL (7th and 14th days), P<0.000 3 and P<0.000 3, respectively (Two-way ANOVA and Tukey test for multiple comparisons). HE, hematoxylin-eosin; CTL, control; DOX10, doxycycline 10 mg·kg−1; DOX25, doxycycline 25 mg·kg−1.
