Figure 7
From: Doxycycline induces bone repair and changes in Wnt signalling
Representative photomicrographs (× 400) of Dkk-1 immunopositive cells in the alveolar tissue on the 7th and 14th days after tooth extraction. There were significant decreases in Dkk-1 immunostaining for both protocols after DOX treatment, as compared with that in the CTL. (a) vs CTL (14th day), P=0.007 4; (b–d) vs CTL (7th and 14th days) and vs DOX25 (7th day), P=0.000 1, P=0.000 1 and P=0.024 8, respectively; (e–g) vs CTL (7th and 14th days) and DOX10 (14th day), P=0.000 1, P=0.002 2 and P=0.000 4, respectively; (h–j) vs CTL (7th and 14th days) and vs DOX25 (14th day), P=0.000 1, P=0.000 1 and P=0.006 2, respectively; (k, l) vs CTL (7th and 14th days), P=0.000 1 and P=0.000 2, respectively (Two-way ANOVA and Tukey test for multiple comparisons). Dkk, Dickkopf; CTL, control; DOX10, doxycycline 10 mg·kg−1; DOX25, doxycycline 25 mg·kg−1.
