Abstract
Pseudomonas aeruginosa antibiotic resistance has led to the search of natural compounds, which would competitively block its fucose>fructose/mannose-binding lectin (PA-IIL) that mediates its biofilm formation and adhesion to animal cells. Such compounds were found in human milk (HM) and avian egg whites. The present research has revealed that honey and royal jelly (RJ), which are assigned to protect beehive progeny and are applied for human infection therapy, match HM in PA-IIL blocking. The function of their fructose (higher in honey) and mannosylated glycoproteins (higher in RJ) as powerful decoys in PA-IIL neutralization is of ecological/biological importance and implementability for the antibacterial adhesion therapeutic strategy.
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Acknowledgements
The authors express their gratitude to Ms Sharon Victor and Ms Ela Gindy for their help in the preparation of this manuscript and its graphic presentation. This work is part of the PhD thesis of KZ-Y in Bar-Ilan University.
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Lerrer, B., Zinger-Yosovich, K., Avrahami, B. et al. Honey and royal jelly, like human milk, abrogate lectin-dependent infection-preceding Pseudomonas aeruginosa adhesion. ISME J 1, 149–155 (2007). https://doi.org/10.1038/ismej.2007.20
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DOI: https://doi.org/10.1038/ismej.2007.20
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