Table 5 Over-/under-representation of bacterial families of OTUs differentially abundant between health states of P. duerdeni and P. lutea, and congregated fold-change differences between healthy (HH) and diseased (DD) specimens (only families that were represented by at least five bacterial taxa were considered)

Bacterial family	OTU count ANOVA (total 629)	OTU count PhyloChip (total 14 213)	Chi-square	P-value	Mean fold-change difference between HH vs DD P. duedeni	Mean fold-change difference between HH vs DD P. lutea
More abundant in HH
Aquabacteriaceae	12	134	0.1030	ns	1.80	2.60
Bacillaceae	9	211	0.3936	ns	1.15	1.21
Burkholderiaceae	7	332	0.0000	ns	1.16	2.19
Comamonadaceae	6	903	18.3660	<0.0001	1.69	2.89
Enterobacteriaceae	20	801	6.4893	<0.01	1.41	2.07
Moraxellaceae	10	163	0.6779	ns	2.35	2.66
Streptococcaceae	23	209	17.3175	<0.0001	2.39	1.91
Xanthomonadaceae	7	120	0.2089	ns	2.48	3.29
More abundant in DD
Alteromonadaceae	5	95	0.0171	ns	1.35	1.61
Clostridiaceae	5	176	0.6491	ns	1.78	6.41
Colwelliaceae	6	20	18.3660	<0.0001	3.94	4.08
Corynebacteriaceae	17	632	3.9726	<0.05	1.13	2.17
Flavobacteriaceae	27	629	0.0035	ns	3.18	2.97
Lachnospiraceae	35	1508	15.9206	<0.0001	1.22	1.73
Oceanospirillaceae	9	264	23.8756	<0.0001	5.35	7.84
Pelagibacteraceae	8	258	0.7250	ns	2.55	2.33
Pseudomonadaceae	57	797	12.6293	<0.001	3.12	4.66
Rhizobiaceae	11	97	8.0640	<0.01	3.58	1.93
Rhodobacteraceae	178	355	1150.8208	<0.0001	5.28	7.11
Rhodospirillaceae	9	36	0.0054	ns	2.39	2.79
Rikenellaceae II	7	146	3.3470	ns	1.83	1.55
Ruminococcaceae	11	616	9.3196	<0.01	1.15	1.01
Sphingomonadaceae	5	142	0.0901	ns	1.75	1.30
unclassified	25	618	0.1224	ns	1.73	1.48
Vibrionaceae	12	310	4.8116	<0.05	5.46	4.38

Abbreviations: ANOVA, analysis of variance; NS, not significant; OTU, operational taxonomic unit.

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