Figure 4

Central carbon metabolism in B. azoricus symbionts. (a) In the thiotrophic symbiont. (b) In the methanotrophic symbiont. Eda: KHG/KDPG aldolase, GlgB: 1,4-alpha-glucan branching enzyme, Mdh: Malate dehydrogenase, ME: malic enzyme, Odh: 2-oxoglutarate dehydrogenase, PpsA: PEP synthase, Sdh: succinate dehydrogenase. For functions of enzymes that were detected as proteins in this study refer to Supplementary Table S3. Protein abundances correspond to average OrgNSAF% in the respective organism from whole gill tissue samples (in Velos MS/MS measurements, see Supplementary Table S3). See Supplementary Table S2B for genome assemblies used for gene prediction. Multiple arrows indicate multiple enzymatic steps. Dotted arrows indicate enzymes that are missing in the respective symbiont’s genome. Sizes are not drawn to scale.