Abstract
New insecticidal antibiotics designated hydroxyfungerins A and B were isolated from the culture broth of a fungal strain Metarhizium sp. FKI-1079 together with a known compound, fungerin. The structures of hydroxyfungerins A and B were elucidated by spectroscopic studies including various NMR experiments. Hydroxyfungerins A and B showed growth inhibitory activity against brine shrimps, Artemia salina.
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References
Fukuda T, Arai M, Tomoda H, Ōmura S . New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. II. Structure elucidation. J Antibiot 57: 117–124 ( 2004)
Fukuda T, Arai M, Yamaguchi Y, Masuma R, Tomoda H, Ōmura S . New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot 57: 110–116 ( 2004)
Matsuda D, Namatame I, Tomoda H, Kobayashi S, Zocher R, Kleinkauf H, Ōmura S . New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979. J Antibiot 57: 1–9 ( 2004)
Yamamoto K, Hatano H, Arai M, Shiomi K, Tomoda H, Ōmura S . Structure elucidation of new monordens produced by Humicola sp. FO-2942. J Antibiot 56: 533–538 ( 2003)
Arai M, Yamamoto K, Namatame I, Tomoda H, Ōmura S . New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942. J Antibiot 56: 526–532 ( 2003)
Kim YP, Tomoda H, Iizima K, Fukuda T, Matsumoto A, Takahashi Y, Ōmura S . Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot 56: 448–453 ( 2003)
Fukuda T, Kim YP, Iizima K, Tomoda H, Ōmura S . Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. II. Structure elucidation. J Antibiot 56: 454–458 ( 2003).
Tomoda H, Tabata N, Ohyama Y, Ōmura S . Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase. J Antibiot 56: 24–29 ( 2003)
Kato Y, Koshino H, Uzawa J, Anzai K . Fungerin, a new antifungal alkaloid from Fusarium sp. Biosci Biotech Biochem 60: 2081–2083 ( 1996)
Taylor HD, Knoche L, Granville WC . Color Harmony Manual, 4th Ed. Container of America, Chicago ( 1958)
Ōmura S, Enomoto Y, Shinose M, Takahashi Y, Iwai Y, Shiomi K . Isolation and structure of a new antibiotic viridomycin F produced by Streptomyces sp. K96-0188. J Antibiot 52: 61–64 ( 1999)
Domsch KH, Gams W, Anderson TH . Compendium of Soil Fungi, Vol. 1. IHW-Verlag, pp. 413–415 ( 1993)
Barron GL . The Genera of Hyphomycetes from Soil. pp. 222–225 ( 1968)
Visconti A, Solfrizzo M . Isolation, characterization, and biological activity of visoltricin, a novel metabolite of Fusarium tricinctum. J Agric Food Chem 42: 195–199 ( 1994)
Visconti A, Solfrizzo M . Visoltricin, a novel biologically active compound produced by Fusarium tricinctum. Food Addit. Contam. 12: 515–519 ( 1995)
Rieder JM, Lepschy J . Synthesis of visoltricin and fungerin: imidazole derivatives of Fusarium sp. Tetrahedron Lett 43: 2375–2376 ( 2002)
Koizumi Y, Arai M, Tomoda H, Ōmura S . Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization. J Antibiot 57: 415–420 ( 2004)
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Uchida, R., Imasato, R., Yamaguchi, Y. et al. New Insecticidal Antibiotics, Hydroxyfungerins A and B, Produced by Metarhizium sp. FKI-1079. J Antibiot 58, 804–809 (2005). https://doi.org/10.1038/ja.2005.107
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DOI: https://doi.org/10.1038/ja.2005.107
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