Abstract
During our screening for microbial inhibitors of lipid droplet accumulation in macrophages, a new compound designated spylidone was isolated along with two structurally related known compounds, PF1052 and vermisporin, from the fermentation broth of Phoma sp. FKI-1840 by solvent extraction, silica gel column chromatography, ODS column chromatography and preparative HPLC. From the structure elucidation, spylidone has a spiro ring containing 2,4-pyrrolidinedione. Among the three compounds, only spylidone was found to inhibit lipid droplet accumulation in macrophages at 10∼50 µM without any cytotoxic effect.
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Koyama, N., Nagahiro, T., Yamaguchi, Y. et al. Spylidone, a Novel Inhibitor of Lipid Droplet Accumulation in Mouse Macrophages Produced by Phoma sp. FKI-1840. J Antibiot 58, 338–345 (2005). https://doi.org/10.1038/ja.2005.42
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DOI: https://doi.org/10.1038/ja.2005.42
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