Abstract
In our systematic screening programme for marine actinomycetes, a bioactive streptomycete was isolated from marine sediment samples of the Bay of Bengal, India. The isolate yielded a new cytotoxic compound. This was obtained by solvent extraction followed by chromatographic purification. The pure compound was identified from spectroscopic data as a quinone-related antibiotic, 1-hydroxy-1-norresistomycin (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro. It also exhibited antibacterial activities against Gram-positive and Gram-negative bacteria.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Mukku VJRV, Speitling M, Laatsch H, Helmke E . Marine bacteria, XII: New butenolides from two marine streptomycetes. J Nat Prod 63: 1570–1572 ( 2000)
Cho KW, Lee HS, Rho JR, Shin J . New lactone-containing metabolites from a marine-derived bacterium of the genus Streptomyces. J Nat Prod 64: 664–667 ( 2001)
Sasaki T, Igarashi Y, Saito N, Furumai T . Watasemycins A and B, new antibiotics produced by Streptomyces sp. TP-A0597. J Antibiot 55: 249–255 ( 2002)
Malet-Cascon L, Romero F, Espliego-Vanzquez, Gravlos D, Fernandez-Puentes JL . IB-00208, a new cytotoxic polycyclic xanthone produced by a Marine-derived Actinomadura. J Antibiot 56: 219–225 ( 2003)
Maskey RP, Helmke E, Laatsch H . Himalomycin A and B: Isolation and structure elucidation of new fridamycin type antibiotics from a marine Streptomyces isolate. J Antibiot 56: 942–949 ( 2003)
Feling RH . Salinosporamide A, a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the genus salinospora. Angew Chem Int Ed Engl 42: 355–357 ( 2003)
Shirling EB, Gottlieb D . Methods for classification of Streptomyces species. Int J Syst Bact 16: 313–340 ( 1966)
Waksman SA . ( Ed). Classification, identification and description of genera and species. In The Actinomycetes, Vol 2. pp 328–334. Williams & Wilkins, Baltimore ( 1961)
Arai T . ( Ed). Culture Media for Actinomycetes. The Society for Actinomycetes, Japan ( 1975)
Lechevalier HA, Lechevalier MP . A critical evaluation of the genera of aerobic actinomycetes. In The Actinomycetales, Prauser (Ed): The Actinomycetales. pp 393–405. Jena, Gustav Fischer Verlag ( 1970)
Staneck JL, Roberts GD . Simplified approach to identification of aerobic actinomycetes by thin-layer chromatography. Appl Microbiol 28: 226–231 ( 1974)
Grever MR, Schepartz SA, Chabner BA . The National Cancer Institute: Cancer drug discovery and development program. Semin Oncol 19: 622–638 ( 1992)
Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kennedy S, Boyd MR . New colorimetric cytotoxicity assay for anticancer drug screening. J Nat Cancer Inst 82: 1107–1112 ( 1990)
Brockmann H, Mayler E, Schrempp K, Reiners F, Reschke T . Resistomycin, IV. Constitution of resistomycin. Chem Ber 102: 1224–1246 ( 1969)
Hofle G, Wolf H . Isolation, 13C-NMR spectra, and biosynthesis of resistomycin and resistoflavin from Streptomyces griseoflavus B71 (Actinomycetales). Liebigs Ann Chem 835–843 ( 1983)
Author information
Authors and Affiliations
Corresponding author
Additional information
†The same compound (1-hydroxy-1-norresistomycin) which was isolated independently from different strains appears in this issue (pages 530-534).
Rights and permissions
About this article
Cite this article
Gorajana, A., Kurada, B., Peela, S. et al. 1-Hydroxy-1-norresistomycin, a New Cytotoxic Compound from a Marine Actinomycete, Streptomyces chibaensis AUBN1/7 †. J Antibiot 58, 526–529 (2005). https://doi.org/10.1038/ja.2005.72
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1038/ja.2005.72
Keywords
This article is cited by
-
Interaction of marine Streptomyces compounds with selected cancer drug target proteins by in silico molecular docking studies
Interdisciplinary Sciences: Computational Life Sciences (2013)
