Abstract
Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonstrate that lichen-associated fungi potentially are a good resource for new bioactive natural products for current screening programs.
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References
Crittenden PD, David JD, Hawksworth DL, Campbell PS . Attempted isolation and success in the culturing of a broad spectrum of lichen-forming and lichenicolous fungi. New Phytol 130: 267–297 ( 1995)
Lawrey J, Diederich P . Lichenicolous fungi: Interaction, evolution, and biodiversity. Bryologist 160: 80–120 ( 2003)
Crittenden PD, Porter N . Lichen-forming fungi: Potential sources of novel metabolites. Trends Biotechnol 9: 409–414 ( 1991)
Seephonkai P, Isaka M, Kittakoop P, Palittapongarnpim P, Kamchonwongpaisan S, Tanticharoen M, Thebtaranonth Y . Evaluation of antimycobacterial, antiplasmodial and cytotoxic activities of preussomerins isolated from the lichenicolous fungus Microsphaeropsis sp. BCC 3050. Planta Medica 68: 45–48 ( 2002)
Takenaka Y, Tanahashi T, Nagakura N, Itoh A, Hamada N . Three isocoumarins and a benzofuran from the cultured lichen mycobionts of Pyrenula sp. Phytochemistry 65: 3119–3123 ( 2004)
Lilly VG, Barnett HL . Physiology of Fungi. McGraw-Hill, New York ( 1951)
Kornerup A, Wanscher JH . Methuen Handbook of Colour, 3rd ed. Eyre Methuen Co., London ( 1978)
Yada H, Sato H, Toshima H, Deura M, Ichihara A . (−)-Semivioxanthin, a new abscisic active compound against Hinoki cypress leaves isolated from Cryptosporiopsis abietina. Biosci Biotechnol Biochem 65: 484–486 ( 2001)
Drochner D, Muller M . Total synthesis of (R)- and (S)-semi-vioxanthin. Eur J Org Chem 1: 211–215 ( 2001)
Scudamore KA, Clarke JH, Hetmanski MT . Isolation of Penicillium strains producing ochratoxin A, citrinin, xanthomegnin, viomellein and vioxanthin from stored cereal grains. Lett Appl Microbiol 17: 82–87 ( 1993)
Suzuki K, Nozawa K, Nakajima S, Kawai K . Structure revision of mycotoxin, viriditoxin, and its derivatives. Chem Pharm Bull 38: 3180–3181 ( 1990)
Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, Gonzalez A, Cully D, Bramhill D, Singh S . Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. J Biol Chem 278: 44424–44428 ( 2003)
Singh PD, Johnson JH, Aklonis CA, Bush K, Fisher SM, O'Sullivan J . Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties. J Antibiot 38: 706–712 ( 1985)
NCCLS. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standards: M7∼A5, Vol. 19. National Committee for Clinical Laboratory Standards, Villanova ( 2000)
Elix JA, Wardlaw JH . Pigmentosin A, a new naphthopyrone from the lichen Hypotrachyna immaculata. Australian J Chem 57: 681–683 ( 2004)
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He, H., Bigelis, R., Yang, H. et al. Lichenicolins A and B, New Bisnaphthopyrones from an Unidentified Lichenicolous Fungus, Strain LL-RB0668. J Antibiot 58, 731–736 (2005). https://doi.org/10.1038/ja.2005.99
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DOI: https://doi.org/10.1038/ja.2005.99
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