Abstract
Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 µM, respectively.
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Uchida, R., Kim, YP., Namatame, I. et al. Sespendole, a New Inhibitor of Lipid Droplet Synthesis in Macrophages, Produced by Pseudobotrytis terrestris FKA-25. J Antibiot 59, 93–97 (2006). https://doi.org/10.1038/ja.2006.13
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DOI: https://doi.org/10.1038/ja.2006.13
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