Abstract
A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5′-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC50 values of 0.23 and 19.6 μg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 μg/ml.
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Li, YQ., Li, MG., Li, W. et al. Griseusin D, a New Pyranonaphthoquinone Derivative from a Alkaphilic Nocardiopsis sp.. J Antibiot 60, 757–761 (2007). https://doi.org/10.1038/ja.2007.100
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DOI: https://doi.org/10.1038/ja.2007.100
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