Abstract
Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sensitive strains of Plasmodium falciparum. Simaomicin α exhibited remarkably strong antimalarial activity, although its activity against a drug-resistant strain was weaker than that against a drug-sensitive strain. The antimalarial effects of triacsins C and D are also reported.
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Ui, H., Ishiyama, A., Sekiguchi, H. et al. Selective and Potent In Vitro Antimalarial Activities Found in Four Microbial Metabolites. J Antibiot 60, 220–222 (2007). https://doi.org/10.1038/ja.2007.27
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DOI: https://doi.org/10.1038/ja.2007.27
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