Abstract
Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.
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Futamura, Y., Tashiro, E., Hironiwa, N. et al. Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.. J Antibiot 60, 582–585 (2007). https://doi.org/10.1038/ja.2007.74
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DOI: https://doi.org/10.1038/ja.2007.74
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