Abstract
A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer “Verrucosispora maris” AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown γ-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.
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†Art. No. 42 in 'Biosynthetic Capacities of Actinomycetes'. Art. No. 41: see ref. 1
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Fiedler, HP., Bruntner, C., Riedlinger, J. et al. Proximicin A, B and C, Novel Aminofuran Antibiotic and Anticancer Compounds Isolated from Marine Strains of the Actinomycete Verrucosispora†. J Antibiot 61, 158–163 (2008). https://doi.org/10.1038/ja.2008.125
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DOI: https://doi.org/10.1038/ja.2008.125
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