Abstract
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillinresistant S. aureus and quinolone-resistant S. aureus with MIC (μg/ml) of 0.5, which is similar with that of vancomycin, but 8∼64 times higher activity than that of tetracycline.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Levy SB, Marshall B . Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10: S122–S1129 ( 2004)
Pfeltz RF, Wilkinson BJ . The escalating challenge of vancomycin resistance in Staphylococcus aureus. Curr Drug Targets-Infect Disord 4: 273–294 ( 2004)
Hutchison RD, Steyn PS, Van Rensburg SJ . Viridicatumtoxin, a new mycotoxin from Penicillium viridicatum Westling. Toxicol Appl Pharmacol 24: 507–509 ( 1973)
Raju MS, Wu GS, Gard A, Rosazza JP . Microbial transformation of natural antitumor agents. 20. Glucosylation of viridicatumtoxin. J Nat Prod 45: 321–327 ( 1982)
Silverton JV, Kabuto C, Akiyama T . The structure and absolute configuration of viridicatumtoxin: 2′S-(2′α,7′αβ,11′αβ,12′β)-7′,7′a,8′,11′,11′a,12′-hexahydro-5′,6′,7′a,10′,11′a,12′-hexahydroxy-3′-methoxy-2,6,6-trimethyl-7′,8′-dioxospiro[2-cyclohexene-1,2′(1′H)-cyclopenta[de]naphthacene]-9′-carboxamide methanolate. Acta Cryst B38: 3032–3037 ( 1982)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zheng, CJ., Yu, HE., Kim, EH. et al. Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11. J Antibiot 61, 633–637 (2008). https://doi.org/10.1038/ja.2008.84
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1038/ja.2008.84
Keywords
This article is cited by
-
A brief history of antibiotics and select advances in their synthesis
The Journal of Antibiotics (2018)
-
Inhibition of bacterial undecaprenyl pyrophosphate synthase by small fungal molecules
The Journal of Antibiotics (2016)
-
AN483, a new anti-MRSA compound from Streptomyces sp.
The Journal of Antibiotics (2016)
-
Isodeoxyhelicobasidin, a novel human neutrophil elastase inhibitor from the culture broth of Volvariella bombycina
The Journal of Antibiotics (2009)
