Abstract
Static fermentation of amidepsine-producing fungus Humicola sp. FO-2942 led to the production of six new amidepsines, including a new type of glycosylated congener. Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC50 value of 40 μM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.
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Acknowledgements
We express our thanks to Ms N Sato for NMR experiments, and to Ms T Sakabe and Ms A Nakagawa for mass spectra.
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Inokoshi, J., Takagi, Y., Uchida, R. et al. Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942. J Antibiot 63, 9–16 (2010). https://doi.org/10.1038/ja.2009.110
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DOI: https://doi.org/10.1038/ja.2009.110
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