Abstract
Gombapyrones A–D, new members of the α-pyrone family of secondary metabolites, were produced by Streptomyces griseoruber Acta 3662, which was isolated from bamboo tree rhizosphere. The strain was characterized by its morphological and chemotaxonomical features and by 16S rDNA sequencing as S. griseobuber. The gombapyrone structures were determined by mass spectrometry and by NMR experiments, and were found to have an inhibitory activity against protein tyrosine phosphatase 1B and glycogen synthase kinase 3β.
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Acknowledgements
Financial support from the European Commission (project ACTAPHARM, 5th framework, QLK3-CT-2001-01783, and project ACTINOGEN, 6th framework, LSHM-CT-2004-005224) and from Bayer Schering Pharma AG (Berlin, Germany) is gratefully acknowledged.
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Article no. 52 in ‘Biosynthetic Capacities of Actinomycetes’. Article no. 51: see reference 1.
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Helaly, S., Schneider, K., Nachtigall, J. et al. Gombapyrones, new α-pyrone metabolites produced by Streptomyces griseoruber Acta 3662. J Antibiot 62, 445–452 (2009). https://doi.org/10.1038/ja.2009.70
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DOI: https://doi.org/10.1038/ja.2009.70
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