Abstract
Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows a strong activity against acid-fast bacilli such as the Mycobacterium and Gordonia species. Nocardithiocin was highly active against rifampicin-resistant as well as -sensitive Mycobacterium tuberculosis strains, and most of the resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 μg ml−1. The structure of the thiopeptide antibiotic containing thiazole, natural and unnatural amino acids was elucidated by MS and NMR spectral analyses.
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Acknowledgements
This work was partially supported by a Grant from Daiichi Pharmaceutical Co. (presently Daiichi-Sankyo Pharmaceutical Co.) Ltd, Chiba, Japan.
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Mukai, A., Fukai, T., Hoshino, Y. et al. Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757. J Antibiot 62, 613–619 (2009). https://doi.org/10.1038/ja.2009.90
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DOI: https://doi.org/10.1038/ja.2009.90
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