Abstract
Three new sterigmatocystin derivatives, oxisterigmatocystin A (1), oxisterigmatocystin B (2) and oxisterigmatocystin C (3), together with one known compound, 5-methoxysterigmatocystin (4), were isolated from the deep-sea-derived fungus Aspergillus versicolor. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1–4 were evaluated against the A-549 and HL-60 cell lines. Compound 4 exhibited moderate cytotoxicities against the A-549 and HL-60 cell lines with IC50 value of 3.86 and 5.32 μM, respectively.
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Acknowledgements
This work was financially supported by the Chinese National Science Fund (No. 30772640 and 30973627) and the Shandong Provincial Natural Science Fund (No. ZR2009CZ016). The antitumor assay was performed at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences. We also thank Dr Wendy Strangman of UBC for the advice on the manuscript.
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Cai, S., Zhu, T., Du, L. et al. Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor. J Antibiot 64, 193–196 (2011). https://doi.org/10.1038/ja.2010.154
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DOI: https://doi.org/10.1038/ja.2010.154
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