Abstract
A new bis-naphtho-γ-pyrone isomer named isochaetochromin A1 was isolated along with known isochaetochromins B1 and B2 from the culture broth of Penicillium sp. FKI-4942 by solvent extraction, silica gel column chromatography and HPLC. Among them, isochaetochromin B1 showed the most potent inhibitory activity of triacylglycerol synthesis with an IC50 value of 5.6 μM, followed by isochaetochromins B2 (IC50, 11 μM) and A1 (33 μM).
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Acknowledgements
We express our thanks to Dr K Hanada (National Institute of Infectious Diseases, Tokyo, Japan) for kindly providing CHO-K1 cells. This work was supported by a grant-in-aid for Scientific Research (B) 18390008 (to HT) from the Ministry of Education, Culture, Sports, Science and Technology of Japan and by the Uehara Memorial Foundation (to HT).
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Ugaki, N., Matsuda, D., Yamazaki, H. et al. New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: I. Taxonomy, fermentation, isolation and biological properties. J Antibiot 65, 15–19 (2012). https://doi.org/10.1038/ja.2011.105
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DOI: https://doi.org/10.1038/ja.2011.105
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