Abstract
Two new acid sorbicillin analogues, (E)-6-(2,4-dihydroxyl-5-methylphenyl)-6-oxo-2-hexenoic acid (1) and 6-(2,4-dihydroxyl-5-methylphenyl)-6-oxohexanoic acid (2), together with 12 known compounds, were isolated from a saline lands-derived fungus Trichoderma sp. The structures of the new compounds were established by interpretation of their spectroscopic data. Their cytotoxic effects on P388 and HL-60 cell lines were preliminarily evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) method. Furthermore, the new compounds exhibited weak radical scavenging activity against DPPH (1,1-diphenyl-2-picrylhydrazyl).
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Verma, M., Brar, S. K., Tyagi, R. D., Surampalli, R. Y. & Valero, J. R. Antagonistic fungi, Trichoderma spp.: Panoply of biological control Biochem. Eng. J. 37, 1–20 (2007).
Montero, M., Sanz, L., Rey, M., Monte, E. & Llobell, A. BGN16.3, a novel acidic β-1,6-glucanase from mycoparasitic fungus Trichoderma harzianum CECT 2413. FEBS J 272, 3441–3448 (2005).
Ruiz, N. et al. New Trichobrachins, 11-residue peptaibols from a marine strain of Trichoderma longibrachiatum. Peptides 28, 1351–1358 (2007).
Macias, F. A. et al. Bioactive carotanes from Trichoderma virens. J. Nat. Prod. 63, 1197–1200 (2000).
Abe, N., Sugimoto, O., Hirota, A. & Murata, T. Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus. Biosci. Biotechnol. Biochem. 62, 661–666 (1998).
Abe, N., Murata, T. & Hirota, A. Novel oxidized sorbicillin dimmers with 1,1-diphenyl-2-picryldrazyl-radical scavenging activity from a fungus. Biosci. Biotechnol. Biochem. 62, 2120–2126 (1998).
Abe, N., Yamamoto, K. & Hirota, A. Novel fungal metabolites, demethylsorbicillin and oxosorbicillinol, isolated from Trichoderma sp. USF-2690. Biosci. Biotechnol. Biochem. 64, 620–622 (2000).
Du, L. et al. Cytotoxic sorbicillinoids and bisorbicillinoids from a marine-derived fungus Trichoderma sp. Chem. Pharm. Bull. 57, 220–223 (2009).
Acknowledgements
This work was financially supported by the Natural Science Foundation of Shandong Province, China (No.Y2008B17). The working strain, Trichoderma sp JH8, was identified by Dr Tianjiao Zhu (Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China.). We appreciate Professor Qianqun Gu, Ocean University of China, for HRESIMS measurements and beneficial discussion.
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Ma, L., Liu, W., Huang, Y. et al. Two acid sorbicillin analogues from saline lands-derived fungus Trichoderma sp.. J Antibiot 64, 645–647 (2011). https://doi.org/10.1038/ja.2011.54
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DOI: https://doi.org/10.1038/ja.2011.54
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