Abstract
Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture broth of an actinomycete of the genus Actinomadura. Its structure was established by spectroscopic methods, and the absolute configuration was determined by a combination of NOESY experiment, J-based configuration analysis and the modified Mosher method. Nomimicin (1) showed antimicrobial activity against Micrococcus luteus, Candida albincans and Kluyveromyces fragilis.
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We acknowledge Dr T Okuda and Ms Y Sudoh at Tamagawa University for assistance with antimicrobial assay.
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Igarashi, Y., Iida, T., Oku, N. et al. Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura. J Antibiot 65, 355–359 (2012). https://doi.org/10.1038/ja.2012.30
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DOI: https://doi.org/10.1038/ja.2012.30
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