Abstract
Cylindrol A5, a new ascochlorin congener, was isolated along with 14 known compounds from the culture broth of Cylindrocarpon sp. FKI-4602 by solvent extraction, octadecylsilane column chromatography and HPLC. The structure of cylindrol A5 was elucidated by spectral analyses, including NMR. The compound has an ascochlorin skeleton consisting of a resorcin aldehyde and a cyclohexanone moieties. Cylindrol A5 showed moderate antimicrobial activity against Bacillus subtilis, Kocuria rhizophila, Mycobacterium smegmatis and Acholeplasma laidlawii. The biosynthetic pathway to cylindrol A5 was deduced from the 14 isolated metabolites of the fungal strain.
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Kawaguchi, M., Fukuda, T., Uchida, R. et al. A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602. J Antibiot 66, 23–29 (2013). https://doi.org/10.1038/ja.2012.75
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DOI: https://doi.org/10.1038/ja.2012.75
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