Abstract
In the course of our screening for inhibitors of lipopolysaccharide (LPS) binding to cellular receptor CD14, potent inhibitory activity was detected in the cultured broth of Pedobacter sp. SANK 72003. Three active compounds, pedopeptin A, B and C, were isolated from the broth and their structures were elucidated by physicochemical and spectral data to be new cyclic depsipeptides.
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Acknowledgements
We are deeply grateful to Dr Toshio Takatsu for his useful advice and Mr Yasuyuki Takamatsu for isolation of the pedopeptins.
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Hirota-Takahata, Y., Kozuma, S., Kuraya, N. et al. Pedopeptins, novel inhibitors of LPS: Taxonomy of producing organism, fermentation, isolation, physicochemical properties and structural elucidation. J Antibiot 67, 243–251 (2014). https://doi.org/10.1038/ja.2013.122
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DOI: https://doi.org/10.1038/ja.2013.122
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