Table 2 Comparative in vitro activity of compound PM2409 (2), Kocurin (1), vancomycin and metronidazole against C. difficile

From: In vitro antibacterial activities of a thiazolyl peptide antibiotic PM2409

  

Supplemented brucella agar a

Wilkins–Chalgren agar a

Strain

Compound

MIC range b

MIC 50

MIC 90

MIC range b

MIC 50

MIC 90

C. difficile

PM2409 (2)

0.5–1

0.5

1

0.25

0.25

0.25

 

Kocurin (1)

0.12–0.25

0.25

0.5

0.03–0.25

0.12

0.25

 

Vancomycin

1–4

1

4

0.5–4

1

2

 

Metronidazole

0.25–0.5

0.25

0.5

0.25–2

0.5

1

  1. aData shown in the plot are mean of the duplicate results. Values are shown in μg ml−1.
  2. bThe values represent the range of MIC values for all 16 clinical strains of C. difficile.